Antioxidant in Vivo, in Vitro Activity Assessment and Acute Toxicity of Aqueous Extract of Gomphrena Celosioides (amaranthaceae)

Many plants possess antioxidant ingredients that provided efficacy by additive or synergistic activities. Gomphrena celosioides (Amaranthaceae) was used for treatment of icterus, and malaria in Africa. In this study, we evaluated the in vivo, in vitro antioxidant activity and acute toxicity effects of Gomphrena celosioides(Gc). Acute toxicity study was undertaken on 48 rats using 100 to 4000 mg kg 1 of Gc. In vivo antioxidant activity was determined, 20 Rabbits were divided into 4 groups of 5 animals. Group 1 to 2 received Gc 100-200 mg kg per by intraperitoneally during 3days. Group 3 received vitamin C (10 mg kg per day) as a reference antioxidant for comparison. Group4 was treated as control and received only saline (NaCl 0.9%). In each group, a blood sample was taken on the first day (J0) before the extract injection and then after extract injection at days 3(J3), 6 (J6), J9 (J9) and 12 (J12).